| | Salary Man Champ (GCA18 VER. JAA) | 2000 | Konami | salarymc | | 7.00 |
| | Samba de Amigo ver. 2000 | 2000 | Sega | samba2k | | 0.00 |
| | Sammy Medal Game System Bios | 2000 | Sammy | sammymdl | | 0.00 |
| | Secret Agent (Maygay) (EPOCH) (1.3, set 3) (clone of: ep_secag) | 2000 | Maygay | ep_secagb | | 0.00 |
| | Sega Marine Fishing | 2000 | Sega | smarinef | | 0.00 |
| | Sega Strike Fighter (Rev A) | 2000 | Sega | sstrkfgt | | 0.00 |
| | Shanghai Shoryu Sairin (V2.03J) | 2000 | Warashi | shanghss | | 0.00 |
| | Sharkey's Shootout (2.07) (clone of: shrkysht) | 2000 | Stern | shrky_207 | | 0.00 |
| | Sharkey's Shootout (2.11) | 2000 | Stern | shrkysht | | 0.00 |
| | Shin Nihon Pro Wrestling Toukon Retsuden 4 Arcade Edition (TRF1 Ver. A) | 2000 | Capcom / Namco | toukon4 | | 0.00 |
| | Show Hand (Italy) | 2000 | Astro Corp. | showhand | | 7.67 |
 | Silent Scope (ver xxA, Ver 1.00) (clone of: sscope) | 2000 | Konami | sscopea | | 0.00 |
| Silent Scope (ver xxB, Ver 1.20) (clone of: sscope) | 2000 | Konami | sscopeb | | 0.00 |
| Silent Scope (ver xxC, Ver 1.30) (clone of: sscope) | 2000 | Konami | sscopec | | 0.00 |
| Silent Scope (ver xxD, Ver 1.33) | 2000 | Konami | sscope | Unplayable | 3.40 |
 | Silent Scope 2 | 2000 | Konami | sscope2 | Unplayable | 3.67 |
 | Simpsons Bowling (GQ829 UAA) | 2000 | Konami | simpbowl | Sports / Bowling | 7.46 |
| | Sir Winalot (Maygay) (EPOCH) (2.1, set 5) (clone of: ep_srwin) | 2000 | Maygay | ep_srwind | | 0.00 |
| | Skins Game (1.04) (clone of: mwskins) | 2000 | Midway | mwskinso | | 0.00 |
| | Skins Game (1.06) | 2000 | Midway | mwskins | | 0.00 |
